abstract：UNLABELLED:Despite significant advances in surgical procedures and treatment, long-term prognosis for patients with oral cancer remains poor, with survival rates among the lowest of major cancers. Better methods are desperately needed to identify potential malignancies early when treatments are more effective. OBJECTI...

journal_title：Oral oncology

authors： Abram TJ,Floriano PN,Christodoulides N,James R,Kerr AR,Thornhill MH,Redding SW,Vigneswaran N,Speight PM,Vick J,Murdoch C,Freeman C,Hegarty AM,D'Apice K,Phelan JA,Corby PM,Khouly I,Bouquot J,Demian NM,Weinstock YE,

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:To establish the concept that the antigenicity/immunogenicity of ALDH(high) human head and neck squamous cell carcinoma (HNSCC) cancer stem cells (CSC) is distinct from that of ALDH(low) non-CSCs. METHODS:We generated CSC-loaded dendritic cells (DCs) to sensitize autologous peripheral blood T, B lymphocytes...

journal_title：Oral oncology

authors： Prince MEP,Zhou L,Moyer JS,Tao H,Lu L,Owen J,Etigen M,Zheng F,Chang AE,Xia J,Wolf G,Wicha MS,Huang S,Ren X,Li Q

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVES:The introduction of intensity modulated radiation therapy (IMRT) has led to new possibilities in the treatment of head and neck cancer (HNC). Limited information is available on how this more advanced radiation technique affects the oral microflora. In a prospective study we assessed the effects of various a...

journal_title：Oral oncology

authors： Schuurhuis JM,Stokman MA,Witjes MJ,Langendijk JA,van Winkelhoff AJ,Vissink A,Spijkervet FK

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:The long-term results of RTOG 91-11 suggested increased deaths not attributed to larynx cancer after concomitant chemoradiotherapy (CRT) despite no apparent increase in late effects. Because the timing of events was not reported by RTOG 91-11, one possibility is that severe late dysphagia (SLD) develops beyond ...

journal_title：Oral oncology

authors： Ward MC,Adelstein DJ,Bhateja P,Nwizu TI,Scharpf J,Houston N,Lamarre ED,Lorenz R,Burkey BB,Greskovich JF,Koyfman SA

更新日期：2016-06-01 00:00:00

abstract：:Recent studies of the genomic landscape of salivary gland tumors have provided important insights into the molecular pathogenesis of these tumors. The most consistent alterations identified include a translocation-generated gene fusion network involving transcription factors, transcriptional coactivators, tyrosine kin...

journal_title：Oral oncology

authors： Andersson MK,Stenman G

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:This study identifies clinical characteristics associated with HPV-positive oropharynx squamous cell carcinoma (OPSCC) and evaluates predictors of overall survival (OS) in HPV-positive patients undergoing definitive treatment within the National Cancer Data Base (NCDB). MATERIAL AND METHODS:The NCDB was que...

journal_title：Oral oncology

authors： Amini A,Jasem J,Jones BL,Robin TP,McDermott JD,Bhatia S,Raben D,Jimeno A,Bowles DW,Karam SD

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVES:Genetic polymorphisms of genes in cell cycle, apoptosis, and inflammation/immune response pathways may control the mechanisms of HPV clearance and HPV escape of immune surveillance and thus may affect both tumor HPV16 status and possibly related outcomes of squamous cell carcinoma of the oropharynx (SCCOP) p...

journal_title：Oral oncology

authors： Feng Y,Li Y,Zhang Y,Zheng H,Li G

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVES:The staging significance of bone invasion is controversial in oral squamous cell carcinoma (OSCC) cases with tumors measuring 4cm or less according to the American Joint Committee on Cancer (AJCC). Our aim was to retrospectively examine a large group of patients with OSCC to determine the staging significanc...

journal_title：Oral oncology

authors： Kuk SK,Yoon HJ,Hong SD,Hong SP,Lee JI

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVES:Secretory leukocyte protease inhibitor (SLPI) is an innate-immunity protein displaying antimicrobial and anti-inflammatory properties that is found in high concentrations in saliva. The role of extracellular salivary SLPI in head and neck squamous cell carcinoma (HNSCC) remains unclear. Thus, we aimed to eva...

journal_title：Oral oncology

authors： Pierce Campbell CM,Giuliano AR,Torres BN,O'Keefe MT,Ingles DJ,Anderson RL,Teras LR,Gapstur SM

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVES:The advantages of the circulating cell-free DNA (cfDNA) methodology are quick results and the possibility of repeated analysis. The main aim of our study was to establish the relationship of the total cfDNA with patients' clinical characteristics and circulating HPV DNA detection in the blood of patients wit...

journal_title：Oral oncology

authors： Mazurek AM,Rutkowski T,Fiszer-Kierzkowska A,Małusecka E,Składowski K

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVES:A multi-disciplinary team (MDT) is essential in the management of cancer. Head and neck cancer (HNC) is a rare, complex and heterogeneous group of malignancies for which different treatment options are available. However, the potential impact of MDT on the management of HNC has been only poorly evaluated to ...

journal_title：Oral oncology

authors： Bergamini C,Locati L,Bossi P,Granata R,Alfieri S,Resteghini C,Imbimbo M,Fallai C,Orlandi E,Tana S,Iacovelli NA,Guzzo M,Ibba T,Colombo S,Bianchi R,Pizzi N,Fontanella W,Licitra L

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:To assess cause-specific mortality in a large population-based cohort of 14,393 patients treated for squamous cell carcinoma of the oral cavity (OC) or oropharynx (OP) in The Netherlands between 1989 and 2006. PATIENTS AND METHODS:Causes of death were obtained for 94.7% of 9620 patients who had died up to Janu...

journal_title：Oral oncology

authors： van Monsjou HS,Schaapveld M,Hamming-Vrieze O,de Boer JP,van den Brekel MW,Balm AJ

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:Dysphagia is a common and debilitating side effect of chemoradiotherapy. Assessment is difficult; swallowing is multifactorial and studies choose from a range of dysphagia assessments. This study intended to investigate the relationship between swallowing assessments of dysphagia in a cohort of patients and ...

journal_title：Oral oncology

authors： Pedersen A,Wilson J,McColl E,Carding P,Patterson J

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:Human papillomavirus (HPV)-positive tumor status is associated with improved prognosis after disease recurrence in oropharyngeal squamous cell carcinoma (OPSCC). In this study the potential role of survival bias in the relationship between HPV tumor status and the timing of recurrence was evaluated, given co...

journal_title：Oral oncology

authors： Guo T,Rettig E,Fakhry C

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Oral mucositis is a major event increasing treatment costs of head and neck squamous cell carcinoma (HNSCC) patients treated with chemoradiation (CRT). This study was designed to estimate the cost-effectiveness of low-level laser therapy (LLLT) to prevent oral mucositis in HNSCC patients receiving CRT. METH...

journal_title：Oral oncology

authors： Antunes HS,Schluckebier LF,Herchenhorn D,Small IA,Araújo CM,Viégas CM,Rampini MP,Ferreira EM,Dias FL,Teich V,Teich N,Ferreira CG

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:Cancer-associated fibroblasts (CAFs) play an important role in tumor progression and are associated with a poor prognosis. Tumor necrosis factor α (TNFα) has been involved in growth and metastasis associated with epithelial-mesenchymal transition (EMT) in many types of cancers. However, the relationship amon...

journal_title：Oral oncology

authors： Zhou B,Zhuang XM,Wang YY,Lin ZY,Zhang DM,Fan S,Li JS,Chen WL

更新日期：2015-12-01 00:00:00

abstract：:The aim of this study was to compare the outcomes of elective neck dissection (END) with that of a more conservative approach comprising of observation plus therapeutic neck dissection for nodal relapse (OBS), by conducting a meta-analysis of randomized controlled trials (RCTs) that compare these two surgical approach...

journal_title：Oral oncology

authors： Ren ZH,Xu JL,Li B,Fan TF,Ji T,Zhang CP

更新日期：2015-11-01 00:00:00

abstract：:Specific biomarkers are urgently needed for the detection and progression of oral cancer. The objective of this study was to discover cancer biomarkers from oral epithelium through utilizing high throughput quantitative proteomics approaches. Morphologically malignant, epithelial dysplasia, and adjacent normal epithel...

journal_title：Oral oncology

authors： Xiao H,Langerman A,Zhang Y,Khalid O,Hu S,Cao CX,Lingen MW,Wong DTW

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:To assess the relationship between tumor-specific growth rate (TSGR) and oropharyngeal cancer (OPC) outcomes in the HPV era. METHODS/MATERIALS:Primary tumor volume differences between a diagnostic and secondary scan separated ⩾7days without interval treatment were used to estimate TSGR, defined as percent volu...

journal_title：Oral oncology

authors： Murphy CT,Devarajan K,Wang LS,Mehra R,Ridge JA,Fundakowski C,Galloway TJ

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:This study tested the long-term outcomes of sentinel lymph node biopsy (SLNB) for oral tongue squamous cell carcinoma (SCC) during the transition from validation to application phase. MATERIALS AND METHODS:Sensitivity, negative predictive value (NPV), neck control rate, disease-specific survival (DSS), disea...

journal_title：Oral oncology

authors： Chung MK,Lee GJ,Choi N,Cho JK,Jeong HS,Baek CH

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:The present study aimed to clarify the role of Moesin in oral squamous cell carcinoma (OSCC) progression, especially in regulation of cell motility. MATERIALS AND METHODS:Immunohistochemistry and western blotting were used to investigate the expression of Moesin, E-cadherin, p120-catenin and MT1-MMP in norma...

journal_title：Oral oncology

authors： Li YY,Zhou CX,Gao Y

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Several recent studies have shown that incidence of oropharyngeal carcinomas is rising in the Western World. This increase has been attributed to changes in the etiology of oropharyngeal carcinomas with a growing role for infections with Human Papilloma viruses. This nationwide study evaluates and compares t...

journal_title：Oral oncology

authors： van Monsjou HS,Schaapveld M,van den Brekel MW,Balm AJ

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVES:Examine the effect of concordance between p16 overexpression and HR (high risk) HPV DNA status on overall survival in a large series of oropharyngeal squamous cell carcinoma (OPSCC) cases. MATERIALS AND METHODS:A total of 185 patients with primary OPSCC had genomic DNA tested by PCR for the HPV16 E6 and E7 ...

journal_title：Oral oncology

authors： Liu SZ,Zandberg DP,Schumaker LM,Papadimitriou JC,Cullen KJ

更新日期：2015-09-01 00:00:00

abstract：:The purpose of this systematic review and meta-analysis was to evaluate the diagnostic value of salivary biological markers in the diagnosis of head and neck carcinoma. Studies were gathered by searching Cochrane, EMBASE, LILACS, MEDLINE, and PubMed. The references were also crosschecked and a partial grey literature ...

journal_title：Oral oncology

authors： Guerra EN,Acevedo AC,Leite AF,Gozal D,Chardin H,De Luca Canto G

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVES:There is a dearth of prospective evidence regarding cancer of the major salivary glands. Outcomes and management of major salivary gland are based largely on retrospective series spanning many decades and changes in surgical, radiation, imaging and systemic therapy strategies and technique. We sought to repo...

journal_title：Oral oncology

authors： Jegadeesh N,Liu Y,Prabhu RS,Magliocca KR,Marcus DM,Higgins KA,Vainshtein JM,Trad Wadsworth J,Beitler JJ

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVES:While surgery with or without adjuvant radiation therapy (RT) is the standard of care for oral cavity cancer (OCC), a select group requires nonsurgical treatment. We provide a single-institution experience using definitive chemotherapy and RT for primary OCC. MATERIALS AND METHODS:We examined 73 patients wi...

journal_title：Oral oncology

authors： Scher ED,Romesser PB,Chen C,Ho F,Wuu Y,Sherman EJ,Fury MG,Wong RJ,McBride S,Lee NY,Riaz N

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Research has identified significant challenges that patients experience following treatment for head and neck cancer (HNC). These include the physical and emotional impacts of the diagnosis and treatment, which compound weight loss and negatively impact eating ability. There is limited research about the lived ...

journal_title：Oral oncology

authors： Ganzer H,Touger-Decker R,Byham-Gray L,Murphy BA,Epstein JB

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVES:The submental island flap has become increasingly popular in the treatment of intraoral defects following tumor ablation. However, there was concern that the elevation of the pedicled flap might interfere with the efficiency of level I-lymph node dissection and decrease the oncologic prognosis of the patient...

journal_title：Oral oncology

authors： Kramer FJ,Böhrnsen F,Moser N,Schliephake H

更新日期：2015-07-01 00:00:00

abstract：:Our aim of the study was to investigate the precise relationship of repair cross-complementation group 1 (ERCC1) expression and the survival as well as objective response rate to cisplatin-based concurrent chemoradiotherapy (CCRT) and a meta-analysis was conducted to analysis ERCC1's prognostic roles in head and neck ...

journal_title：Oral oncology

authors： Gao Y,Liu D

更新日期：2015-06-01 00:00:00

abstract：:Conventional therapeutic approaches for head and neck squamous cell carcinoma (HNSCC) are associated with many adverse effects that reduce quality of life. Therefore, identification of new less cytotoxic treatments is highly important. Metformin, which is commonly used for type 2 diabetes, may reduce cancer risk. A fe...

journal_title：Oral oncology

authors： Rêgo DF,Pavan LM,Elias ST,De Luca Canto G,Guerra EN

更新日期：2015-05-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) represent 95% of head and neck cancer with an incidence of over half a million people globally. The prognosis for patients with recurrent or metastatic HNSCC is generally poor with low 5-year survival rates despite treatment advances over the past few decades. Consequently...

journal_title：Oral oncology

authors： Martinez-Useros J,Garcia-Foncillas J

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Excision repair crosscomplementing-1 (ERCC1) has been reported to play a prognostic role and may indicate the treatment response in patients with head and neck squamous carcinoma (HNSCC). Nevertheless, the strength of evidence of ERCC1 predicting these two clinical outcomes are still controversial. METHODS:...

journal_title：Oral oncology

authors： Xuelei M,Jingwen H,Wei D,Hongyu Z,Jing Z,Changle S,Lei L

更新日期：2015-05-01 00:00:00

abstract：:The aim of this study was to systematically review the articles investigating the prognostic value of different microRNAs (miRs) in human head and neck squamous cell carcinoma (HNSCC). Following the guidelines of the Meta-analysis of Observational Studies in Epidemiology group (MOOSE), we performed a broad and sensiti...

journal_title：Oral oncology

authors： Jamali Z,Asl Aminabadi N,Attaran R,Pournagiazar F,Ghertasi Oskouei S,Ahmadpour F

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:It is well recognized that oral squamous cell carcinoma (OSCC) cases from Asia that are associated with betel quid chewing are phenotypically distinct to those from Western countries that are predominantly caused by smoking/drinking, but the molecular basis of these differences are largely unknown. The aim o...

journal_title：Oral oncology

authors： Saeed AA,Sims AH,Prime SS,Paterson I,Murray PG,Lopes VR

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Histopathological grading of adenoid cystic carcinoma (ACC) is a controversial issue. It is generally agreed that solid type ACC has a relatively poor prognosis. However, the amount of solid regions within this often mixed type tumor that predicts a poor prognosis is not firmly established. Some authors stip...

journal_title：Oral oncology

authors： van Weert S,van der Waal I,Witte BI,Leemans CR,Bloemena E

更新日期：2015-01-01 00:00:00

abstract：:Stage of disease at the diagnosis of oral cancer is thought to be a significant factor in prognosis and outcome (International Agency for Research on Cancer/World Health Organization, 2014). Unfortunately, we continue to diagnose almost 2/3 of these cancers at advanced stages of disease despite the ongoing research fo...

journal_title：Oral oncology

authors： Güneri P,Epstein JB

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVES:Several studies have investigated the relationship between the use of dentures and the duration of denture use and cancer development. Of particular interest is whether ill-fitting dentures increase the likelihood of the development of oral cancer. We conducted a meta-analysis to determine the relationship b...

journal_title：Oral oncology

authors： Manoharan S,Nagaraja V,Eslick GD

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVES:miR-29b has been implicated in various cancers. However, the role of miR-29b in tongue squamous cell carcinoma (TSCC) remains unclear. This study aimed to investigate the role of miR-29b in TSCC progression. MATERIALS AND METHODS:The expression of miR-29b was analyzed in TSCC tissues and cells. Functional s...

journal_title：Oral oncology

authors： Jia LF,Huang YP,Zheng YF,Lyu MY,Wei SB,Meng Z,Gan YH

更新日期：2014-11-01 00:00:00

abstract：:Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) generates microvascular parameters from the tracer kinetic analysis of a series of MRI images obtained in under 15 min. DCE-MRI parameters are associated with tumour hypoxia, which is well-established as a cause of treatment failure in head and neck squamo...

journal_title：Oral oncology

authors： Bernstein JM,Homer JJ,West CM

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVES:Results of the Dutch multi-institutional trial on sentinel lymph node (SLN) biopsy in oral cancer. PATIENTS AND METHODS:Patients were consecutively enrolled from 4 institutions, with T1/T2 oral cancer and cN0 neck based on palpation and ultrasound guided fine needle aspiration cytology. Lymphatic mapping co...

journal_title：Oral oncology

authors： Flach GB,Bloemena E,Klop WM,van Es RJ,Schepman KP,Hoekstra OS,Castelijns JA,Leemans CR,de Bree R

更新日期：2014-10-01 00:00:00